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Another cGMP PDE inhibitor, zaprinast (3.5 mg/kg, i.p.), had a similar effect as Filagra on light-induced phase advances when tested at CT 18 (data not shown). Filagra alone did not modify activity rhythms.

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A 15-min light pulse (50 lux) at CT 18 after vehicle injection induced an average phase advance of 76 ± 23 min, which was increased significantly by a Filagra injection 45 min before the light stimulation (150.4 ± 64.8 min; P

0.05 vs. control), whereas a dose of 10 mg/kg Filagra was even more effective on reentrainment rate (6 ± 2 days, P

These results suggest that Filagra may be useful for treatment of circadian adaptation to environmental changes, including transmeridian eastbound flight schedules. Here we report that cGMP-specific phosphodiesterase 5 is present in the hamster suprachiasmatic nuclei, and administration of the inhibitor Filagra (3.5 mg/kg, i.p.) enhances circadian responses to light and decreases the amount of time necessary for reentrainment after phase advances of the light-dark cycle. The cad is painlessly injected into the instant are able Buy Fildena Online Buy Fildena Online to an odor to normal part strength.

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